She has revealed for the first time that Daisy has a rare medical condition which she was diagnosed with shortly after her first birthday.
The teenageer is due to undergo a series of operations on her legs after gradually developing circulation problems in her veins over the years.
"Nip/Tuck creator Ryan Murphy said: "It was sad, but Joely came before her character.
She vowed to quit Hollywood to look after her sick daughter.
She has also appeared in films such as 101 Dalmatians (1996), Event Horizon (1997), The Patriot (2000), Return to Me (2000), Anonymous (2011), the Hollywood film adaptation The Girl with the Dragon Tattoo (2011), and the remake of Endless Love (2014).
Richardson was born in Marylebone, London to the theatrical Redgrave family, the daughter of actress Vanessa Redgrave and director Tony Richardson, and the granddaughter of actors Sir Michael Redgrave and Rachel Kempson, Lady Redgrave.
But now, Joely Richardson is filming again and worried friends say she's pushing herself too hard As her chauffeur-driven limo glides through the gates of Hollywood's Paramount Studios, there have been occasions in recent weeks, one suspects, when Joely Richardson has blanched at the thought of what the day's filming holds in store.
In her starring role in plastic surgery drama Nip/Tuck, she has just completed scenes that show her, variously, having sex with beautiful Australian actress Portia de Rossi, getting kidnapped and being sexually abused.
When her only child Daisy was born 15 years ago, actress Joely Richardson was torn between going back to work and being a mother.
It is, of course, all knockabout, postwatershed nonsense, although hardly what one might expect from the scion of British theatrical royalty (Joely's mother is Vanessa Redgrave and her late father was the director Tony Richardson), let alone the 42-year-old mother of a teenage daughter.
But what is, perhaps, most surprising is that the lovely Miss Richardson is in Los Angeles at all.
The director sees plastic surgery as the externalisation of self-hatred." For a time Richardson seemed overshadowed by the achievements of her illustrious family: grandparents (Michael Redgrave and Rachel Kempson), parents (Vanessa Redgrave and Tony Richardson), uncle and aunt (Corin and Lynn Redgrave), and older sister (Natasha Richardson).
But now the success of Nip/Tuck - she was nominated for a Golden Globe for Best Actress in a Drama in 2004 - has placed her in a new league.